Resveratrol Health Benefits l Resveratrol Studies l Antioxidant Benefits of Resveratrol Sources

Researchers from the Department of Cell and Molecular Pharmacology and Experimental Therapeutics and Digestive Disease Center, Medical University of South Carolina, completed a unique study of resveratrol in 2004. The study was intended to determine the amount of resveratrol a human could absorb through oral dose.

Oral Doses of Resveratrol

Resveratrol has long been known to have verified positive impact on a variety of health issues, most notably prevention and suppression of various cancers and heart disease.

Scientific studies have dramatically shown the impact resveratrol (a compound naturally occurring in red wine and grapes) has on cancer cells and lipoproteins. However, the question was raised whether it was feasible that human beings could ingest and absorb enough resveratrol orally to generate the same results as produced in the laboratory. This is the question the team from the Medical University of South Carolina set out to answer.

Conclusion: Low bioavailability of resveratrol when ingested orally

It was discovered that while 70% of the resveratrol doses administered orally was absorbed, most of the resveratrol was soon metabolized and eliminated from the body via urine and feces. Only trace amounts of unchanged resveratrol were found in the bloodstream after a short period of time. These trace amounts do not have the capacity to reproduce the beneficial effects observed in laboratory settings.

Buccal delivery provides greater bioavailability

However, according to another study by Asensi M, Medina I, Ortega A, et al (2002), the most efficient way of administering resveratrol in humans appears to be buccal delivery. This group of researchers found that after keeping the trans-resveratrol compound inside the mouth for up to one minute – without swallowing – the levels of unchanged resveratrol in the bloodstream were 250 times higher to those obtained with pills. These findings make alternative delivery methods such as resveratrol melting tablets, lozenges and chewables more likely to produce the beneficial effects of resveratrol found in the laboratory.

A 1990 study by Yong Nam Han, Shi Yong Ryu, and Byung Hoon Han of the Natural Products Research Institute at Seoul National University in Seoul, Korea conducted at study in which they discovered that the antioxidant activity of resveratrol closely correlates with its ability to inhibit monoamine oxidase-A activity (the activity of molecules with a single amino acid).

Goal of This Study of Resveratrol

Resveratrol, a polyhydroxylstilbene, was reported to inhibit the activity of monoamine oxidase-A. In this study the team from Seoul National University hoped to discover a plausible mechanism by which red wine resveratrol is able to slow the activity level of monoamine oxidase-A.

Researchers first isolated a number of phenolic substances (among them resveratrol) in an attempt to find the most potent inhibitor of monoamine oxidase-A. Components of the study were serotonin and the mitochondrial MAO of rat brain.

Resveratrol as an antioxidant

The study revealed that not only was resveratrol the most powerful antioxidant of the monoamine oxidase-A inhibitors, it completely suppressed MAO-A and became, in the view of the research team, the selective agent for MAO-A inhibiting.

In a 2001 report made by researchers at the Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, and the University of Illinois Cancer Center at the University of Illinois at Chicago K.P.L. Bhat, J.W. Kosmeder II, and J.M. Pezzuto endeavored to summarize the health benefits of the naturally occurring polyphenol resveratrol.

Resveratrol naturally occurs in various plant-derived foods and beverages, such as grapes, peanuts, white and red wine, raw cranberry juice, and so forth. Its health benefits have been observed in the form of cancer prevention and prevention of heart disease among other things.

Antioxidant Benefits of Resveratrol

Resveratrol is a known antioxidant and its ability to promote nitric oxide production is well documented. It has also been shown to increase high-density lipoprotein cholesterol which makes it highly beneficial as a cardiopreventative agent due to the fact that it protects against plaque build up in the arteries.

The estrogenic effect of resveratrol supplements make it a valuable instrument in the fight against breast cancer as it transfects breast cancer cells.

Finally, resveratrol’s anti-inflammatory properties make it useful as a neuroprotective agent. In such cases, resveratrol is able to assist the body in maintaining brain cell health.

Likely, researchers have only scratched the surface of the many health benefits resveratrol has. Additional studies will allow researchers to not only identify the exact mechanisms by which resveratrol positively impacts so many diseases, but also identify additional health issues that can be helped by resveratrol.

G. Calabrese of the Department of Human Nutrition at Universita Cattolica in Piacennza, Italy took a close look at the health benefits of moderate wine consumption as it might impact menopause.

Leading up to this 1999 study, there was a great deal of literature surrounding the health benefits of resveratrol, a polyphenol naturally occurring in many foods and beverages. Its cancer preventative and heart disease preventative characteristics have made red wine resveratrol the focus of many studies. However, Calabrese intended to determine if these health benefits would extend themselves beyond cancer and heart disease and might be an influence on menopause.

Calabrese’s Findings Surrounding Resveratrol

The hypothesis of this study is based on the idea that the structure of resveratrol is so much like that of diethylstilbestrol, a drug prescribed to prevent miscarriages, that it might act as a phytoestrogen in humans.

Calabrese’s team conducted a population study, read literature on resveratrol’s effects on female reproduction, osteoporosis, and cancer, and they conducted various trials of their own.

Their findings concluded that moderate wine consumption appeared to act as a phytoestrogen, a compound in plants that simulates estrogen in humans. Resveratrol doses boosted the physiological reactions that typically accompany estrogen increases.

This activity could effectively moderate the effects and symptoms of menopause in women.

At the School of Life Sciences at Lanzhou University, G.A. Liu and R.L. Zheng conducted research into the ability of polyphenols (groups of chemicals found in plants) to protect healthy cells against diseases like heart disease and cancer at the cellular level.

Seven polyphenols were studied, among them resveratrol.

DNA damage was induced by using hydrogen peroxide on human peripheral blood lymphocytes (PBL) which is known to cause single strand breakage in DNA. The researchers then observed the ability of the seven polyphenols to protect the cells against the damage the hydrogen peroxide was invoking on the cellular DNA.

Resveratrol Provides Significant Cell Protection

Resveratrol, as well as others of the seven tested polyphenols, had a substantial impact on inhibiting cell damage. The impact was dose-dependent as higher doses were more effective in cell protection.

Some of the polyphenols, however, failed to provide any protection. In fact, only three had any effect in protecting the cells against hydrogen peroxide damage (resveratrol, quercetin, and 7.8-dihydroxy-4-methyl coumarin), but these had a big enough impact to convince the researchers that they had discovered a possible mechanism explaining resveratrol’s outstanding track record in protecting against cancer and heart disease.

The Department of Animal Biology-II (Animal Physiology) and the Faculty of Biology at the Compultense University in Madrid, Spain, Drs. S. Cadenas and G. Baria released a study in 1999 reporting that resveratrol, a red wine ingredient, can protect against DNA damage induced by a kidney cancer-causing substance.

Antioxidants melatonin, vitamin E, and resveratrol have free radical scavenger properties that can decrease the damaging effects of free radicals in the environment. These antioxidants can provide preventative and therapeutic advantages.

The research shows that resveratrol completely depleted a dangerous kidney carcinogen and was partially depleted by melatonin and vitamin E. The study also showed that administering a resveratrol dosage prevented an increase in relative kidney weight induced by the cancer-causing agent.

The results proved that resveratrol, among other antioxidants, and a free radical trap can prevent oxygen induced DNA damage in the kidney by the experiment’s cancer causing agent, or carcinogen.

Publishers from Life Science released a study from researchers from the Institute of Experimental Medicine in Rome, Italy in November, 2001 that provides evidence that resveratrol, an ingredient in red wine, may aid in the healthy function of human immune cells.

Drs. R. Falchetti, M.P. Fuggetta, G. Lanzilli, M. Tricarico, and G. Ravagnan published findings showing that red wine resveratrol has a wide range of activities affecting the human immune system.

Antioxidant Resveratrol Jump Starts Immune Cell Production

Resveratrol was shown to jump start immune cell production and growth even at low concentrations. The human immune system produces many types of cells to help protect the body. Resveratrol was seen to affect the production of one such cell called cytokine, which is a type of white blood cell that is involved in cellular reproduction, growth, immunity and tolerance. These types of blood cells are essential for regulating the immune system’s response to infections.

Resveratrol is found in red wine but can also be consumed in supplement form. The benefits of consuming resveratrol supplements are many. Specifically, resveratrol can aid the immune system in producing the many types of white blood cells that are necessary to help the body fight infections and disease.

Other important functions of resveratrol in regard to the immune system include aiding cells in response to ultra violet radiation exposure, free radicals, and bacterial or viral antibodies. Even at very low levels, resveratrol can help activate human immune system responses.