Department of Gastroenterology Report on Anti-Cancer Activity of Resveratrol
Hai-Bo Zhou, Juan-Juan Chen, Wen-Xia Wang, Jian-Ting Cai, and Qin Du of the Department of Gastroenerology in the Second Hospital of Zhejiang University set out to study the effects of resveratrol on stomach cancer. The 2004 study revealed some critical findings about resveratrol.
The researchers transplanted human stomach cancer into the subcutaneous tissue of nude mice to determine resveratrol’s effect on live candidates.
Three different doses of resveratrol were tested (500 mg/kg, 1000 mg/kg, and 1500 mg/kg). The dose was directly injected beside the tumor in each candidate. Changes in tumor size were then monitored.
Effects of Resveratrol on Stomach Cancer Tumors
In all cases, the resveratrol inhibited cell growth significantly. As the dose increased, the inhibition rate also increased. In fact, at 1500 mg/kg inhibition rate reached nearly 40%.
In addition to the growth inhibiting effect, resveratrol also induced cell apoptosis (natural cell death) in the cancer cells. A marked reduction of tumor size was observed.
Resveratrol slowed cell development in the stomach cancer cells at a rate of up to 40% and initiated apoptosis in the gastric carcinoma cells.